Wednesday, 18 June 2014

New Computer Technology By HP



Hardware
With 'The Machine,' HP May Have Invented a New Kind of Computer

If Hewlett-Packard (HPQ) founders Bill Hewlett and Dave Packard are spinning in their graves, they may be due for a break. Their namesake company is cooking up some awfully ambitious industrial-strength computing technology that, if and when it’s released, could replace a data center’s worth of equipment with a single refrigerator-size machine.


 Photograph by Richard Lewington/Hewlett-PackardHP CTO Martin Fink in the Photonics laboratory at HP LabsThat’s what they’re calling it at HP Labs: “the Machine.” It’s basically a brand-new type of computer architecture that HP’s engineers say will serve as a replacement for today’s designs, with a new operating system, a different type of memory, and superfast data transfer. The company says it will bring the Machine to market within the next few years or fall on its face trying. “We think we have no choice,” says Martin Fink, the chief technology officer and head of HP Labs, who is expected to unveil HP’s plans at a conference Wednesday.
A decade ago, it wouldn’t seem as outlandish as it now does for a company such as HP, IBM (IBM), or Sun Microsystems to build a new computer architecture from the ground up. The hardware powerhouses, known as systems companies, all made their own chips, networking technology, and custom OS. Then commodity components became more powerful, and better data center software began to make up for deficiencies in the cheaper hardware. Consumer Web companies such as Google, Amazon.com (AMZN), and Yahoo! (YHOO) advanced new data center designs that were quickly adopted by the mainstream, shrinking the market share of the systems companies.
HP Labs, the company’s R&D arm, was once revered throughout Silicon Valley as a steady source of new products that could open up new markets. It’s been far less inspiring in recent years, ginning up a mishmash of mobile software, printing services, and teleconferencing systems that haven’t made it to customers in a meaningful way. Amid budget cuts, a costly, complex new computer system would seem like a stretch.
The Machine started to take shape two years ago, after Fink was named director of HP Labs. Assessing the company’s projects, he says, made it clear that HP was developing the needed components to create a better computing system. Among its research projects: a new form of memory known as memristors; and silicon photonics, the transfer of data inside a computer using light instead of copper wires. And its researchers have worked on operating systems including Windows, Linux, HP-UX, Tru64, and NonStop.

Photograph by Richard Lewington/Hewlett-PackardA memristor characterization experiment at HP Labs
Fink and his colleagues decided to pitch HP Chief Executive Officer Meg Whitman on the idea of assembling all this technology to form the Machine. During a two-hour presentation held a year and a half ago, they laid out how the computer might work, its benefits, and the expectation that about 75 percent of HP Labs personnel would be dedicated to this one project. “At the end, Meg turned to [Chief Financial Officer] Cathie Lesjak and said, ‘Find them more money,’” says John Sontag, the vice president of systems research at HP, who attended the meeting and is in charge of bringing the Machine to life. “People in Labs see this as a once-in-a-lifetime opportunity.”
Memory represents perhaps the biggest opportunity for change. Computers have worked in a similar way for many years now. When a person wants to do something such as run Microsoft Word, the computer’s central processor will issue a command to copy the program and a document from the slow disk it had been sitting on and bring it temporarily into the high-speed memory known as DRAM that sits near the computer’s core, helping ensure that Word and the file you’re working on will run fast.
A problem with this architecture, according to computing experts, is that DRAM and the Flash memory used in computers seem unable to keep pace with the increase in data use. As the current memory technology hits its physical limits, dozens of companies continue to work on possible replacements. “Everyone on the planet who is paying any attention to this type of thing wants to see this new kind of fast, cheap, persistent memory,” says Greg Papadopoulos, a partner at the venture capital firm New Enterprise Associates. “If one of these things works, and one of them will, it will change computing architecture fundamentally.

Sunday, 15 June 2014

The Future of Computers

The Future of Computers


future of computers

The Future of Computers: From Tubes to Tablets

Recent innovations such as the iPad provide an exciting glimpse into the future of computers. Before looking forward toward future computer trends, let's take a quick look back to gain a better appreciation of the evolution thus far. Do you remember when the first primitive computing machines occupied entire buildings? The massive machines from the mid-20th century consisted of row upon row of vacuum tubes and wires. You had to use stacks of punch cards to program these beasts.

The Future of Computers: Home Computers

Steve Jobs and Bill Gates were both instrumental in bringing the computer down to size. With the introduction of the personal computer and its widespread acceptance, computers shrunk while processing power increased. Even the bulky CRT monitors got a makeover with flat LCD monitors now the norm. In addition, costs have fallen so much over the years that many households own several personal computers and wireless networks. Future technology won't necessarily render the home PC obsolete, but it will change it. For example, modern televisions and appliances are now Web-enabled. Expect future technology to blend appliances into the home network.

The Future of Computers: Laptops, Netbooks, and Ultrabooks

First there were laptops, then there were netbooks, and now there are "ultrabooks." These mobile devices share several characteristics including the integrated folding design and portability. Differences include size and storage (laptops use hard disks, netbooks rely more heavily on the cloud, and ultrabooks use Flash memory). Despite their similarities and differences, future computer trends point to a lesser reliance on keyboards which could potentially render this category obsolete.

The Future of Computers: Tablets

Apple's iPad has significantly influenced future computer trends. It was soon followed by a flood of tablets. With small sizes, simple designs, extreme portability, Internet access, thousands of apps, and loads of features, tablets can do just about anything a full-size desktop or laptop can do. They fall short in the keyboard arena, but again, that may be about to change.

Future Technology: Speech Recognition and Touchscreen Technology

While speech recognition is still imperfect, it has improved greatly in recent years. Windows 7 includes a built-in speech recognition program in its operating system while Nuance's Dragon Naturally Speaking software continues to gain acceptance.
Not only is the keyboard in danger, the mouse is too thanks to touchscreen technology. Tablets and smartphones currently make use of touchscreen technology and many "all in one" desktops now come with touchscreen LCDs. When Windows 8 comes out, it is expected to take the touchscreen into the mainstream.

The Future of Computers has Arrived – Are You Ready?

If history is to be any guide, some of the most powerful advances in the world of computers and computer technology are likely to be completely unforeseen. After all, some of the most powerful technologies of the past have taken us by surprise, so stay tuned for truly fascinating future computer trends. If you're ready to embrace the future of computers, consider getting certified or mastering the skills you need to succeed in today's IT world.


Visit on www.Youtube.com:
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Test Your Personality Based On Your Facebook Posts

Test Your Personality Based On Your Facebook Posts


When you post to Facebook, you're not just sharing news of your most recent meal or weekend trip with your friends. You may unwittingly reveal a bit of your personality, too.
A start up called Five Labs has made a new online tool that it claims can analyze your Facebook posts in order to assess your personality. The site, which is based on a University of Pennsylvania study, looks at the language you use in order to determine different aspects of your personality. Specifically, the page looks at what are called the "Big Five" personality traits: extraversion, openness, neuroticism, conscientiousness and agreeableness.
Once the site has combed through all of the words used in your Facebook statuses -- 1,240 in my case -- it creates a fun little chart of your personality. When I did it, Five Labs said I am inventive, assertive, compassionate, sensitive and efficient.
The site also rates your extraversion, openness, neuroticism, conscientiousness and agreeableness on a percentage scale. Here's how mine broke down:
five labs
The tool may not be as good of a measure of personality as, say, a professionally administered personality test. But it's fun to get an idea of how others might see you on Facebook.
Even better, Five Labs lets you compare your own personality to those of your friends and celebrities. Of course, most public figures don't manage their own Facebook pages, so the comparisons have obvious limits. Still, it's fun.
Much to my delight, I am very similar to Facebook Oprah. In fact, we are an 89 percent match. Obviously, this algorithm doesn't take wealth into account.
five labs
Unfortunately, I'm nothing like Bill Gates. Sigh.
five labs
Maybe I'll take it again in a few years.

Thursday, 5 June 2014

Why HR Pros will Turn to Video Conferencing in 2016

98 per cent of HR executives surveyed say video conferencing helps companies defy distance and break down cultural barriers to improve productivity.

HR executives who use video at work today say they will prefer video collaboration over email as their top method of business communication within three years, says a survey by Redshift Research and Polycom.

The majority of those respondents (56 per cent) indicated video would be their most preferred method of business communication, surpassing email (49 per cent) and voice conference calls (32 per cent).



Proving that the benefits of video for HR functions are well understood, the survey of business decision makers in 12 countries revealed that almost all (98 per cent) of the HR executives participating in the survey believe video conferencing removes distance barriers and improves productivity between teams in different cities and countries.
The survey also showed that video is becoming more pervasive for Human Resources teams across the globe. When asked to choose their preferred methods of business communication today, HR respondents ranked video conferencing as a top-three tool for communications, placing third (46 per cent) after email (88 per cent) and voice/conference calls (62 per cent).

Other methods of business communications these HR executives said they use included Web conferencing, instant messaging and social media.

The top three reasons identified for this growth in adoption were to reduce travel costs, shorten the time to hire and to reach geographically dispersed candidates “Advancements in technology and telecommunications are allowing organisations large and small to operate seamlessly from anywhere,” said Mollie Lombardi, Vice President and Principal Analyst, Human Capital Management, Aberdeen Group.

“HR leaders require a new understanding of how technology can help them bridge geographical boundaries and rethink their talent strategies to take full advantage of a broader talent pool.” Vanessa Mauree, HR Director of French retail chain Alain Afflelou is already seeing the benefits of using video during the recruitment process. “I interview candidates for positions all over the country. I cannot make a decision from a telephone interview; I need to see the person to make a good evaluation but flying all candidates to Parisis too costly. Video interviews are ideal, and allow me to see more candidates. A good video interview is as effective as an in-person interview,” said Mauree. Beyond recruitment, video is also enabling organisations to implement flexible work environments. 

This is proven to increase productivity, can reduce employee time spent commuting, and can increase staff satisfaction and loyalty by allowing employees to have more control over work-life balance. Voice, video and content collaboration is impacting many facets of the HR function, including retention, engagement, and training. Video conferencing, video recording and video asset management helps organisations overcome diminishing training budgets, minimise scheduling and travel conflicts, and prevent the loss of knowledge through attrition and retirement with easier, more frequent collaboration and on-demand access to training and knowledge. 

5 Ways to Secure Your Android Device

Quick Heal’s threat report for Windows and Android identifies five ways to secure Android device against malware, and the BYOD trend


With such rapid installation and activation of Android devices across the world, knowing how to secure these devices has become imperative. There are many tips that users can easily put into practice that will ensure the security of their smartphones. Such tips can be adopted by enterprise users who adhere to BYOD policies and to home users as well. The five ways include:

 1.      Stay aware about mobile risks
     The best way to ensure safety is to be aware of the various tricks that Android malware uses to infiltrate devices. Apps and programs are the single biggest source of malware, so users should always study the  permissions that an app is asking for upon installation. Moreover, it is highly advisable to refrain from downloading apps from unofficial third-party sources. Always install apps from Google Play only.

2.     Be wary of unsecured Wi-Fi networks
Free Wi-Fi available in public places is a great way to access the web on the move, but there are several ways in which such networks can prove vulnerable. Snoopers can easily intercept and steal data over unsecured Wi-Fi networks, so these should be avoided, especially while dealing with sensitive information.

3.     Be cautious while carrying out online purchases
With e-commerce portals making their presence felt over Android and coming out with snazzy apps and  d coming out with snazzy apps and user interfaces, more and more people are purchasing products through these apps. Online shopping is fun, but not at the cost of security. Without the right safety measures and precautions, financial details can be easily lost or stolen.

4.     Comply with foolproof BYOD security policies
Organizations that encourage BYOD policies often face the repercussions that come with employee negligence and uncontrolled app downloads. In a situation like this, setting up clear, simple and transparent security policies becomes absolutely necessary. When all devices are connected to the enterprise network, it is a major risk when one employee downloads a malicious copy of Flappy Birds. Proper security policies need to be defined and adhered to in order to avoid widespread mayhem.

5.     Embrace an eff­ective and feasible security suite
Where there are risks, there are also solutions. Security suites for Android devices have now become more than just a luxury, they are a necessity. Without proper security in place, the world of Android devices will become a lawless and dangerous place, so everyone who owns an Android should acquire a security solution to go with it. Just as PCs without an antivirus will always be susceptible to all kinds of threats, an Android without a security suite will always remain vulnerable. 

Saturday, 31 May 2014

New Technology for improved driverless cars and video games

New technology for improved driver less cars and video games



Scientists have developed a new 3-D imaging system that can remotely sense objects across distances as long as 30 feet, 10 times farther than what could be done with current low-power laser systems.

The system could one day enable a self-driving car to spot a child in the street half a block away, let people answer their Smartphone from across the room with a wave of hand, or play "virtual tennis" on their driveway.
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The new system relies on LIDAR ("light radar"), a 3-D imaging technology that uses light to provide feedback about the world around it.
LIDAR systems of this type emit laser light that hits an object, and then can tell how far away that object is by measuring changes in the light frequency that is reflected back.
It can be used to help self-driving cars avoid obstacles halfway down the street, or to help video games tell when you are jumping, pumping your fists or swinging a "racket" at an imaginary tennis ball across an imaginary court.
In contrast, current lasers used in high-resolution LIDAR imaging can be large, power-hungry and expensive.
"While meter-level operating distance is adequate for many traditional metrology instruments, the sweet spot for emerging consumer and robotics applications is around 10 meters," said Behnam Behroozpour from the University of California, Berkeley.
Gaming systems require big, bulky boxes of equipment, and you have to stand within a few feet of the system for them to work properly, Behroozpour said.
Bulkiness is also a problem for driverless cars such as Google's, which must carry a large 3-D camera on its roof.
The researchers sought to shrink the size and power consumption of the LIDAR systems without compromising their performance in terms of distance.
The team used a type of LIDAR called frequency-modulated continuous-wave (FMCW) LIDAR, which they felt would ensure their imager had good resolution with lower power consumption, Behroozpour said.
This type of system emits "frequency-chirped" laser light (that is, whose frequency is either increasing or decreasing) on an object and then measures changes in the light frequency that is reflected back.
To avoid the drawbacks of size, power and cost, the team exploited a class of lasers called MEMS tunable VCSELs.

MEMS (micro-electrical-mechanical system) parts are tiny micro-scale machines that, in this case, can help to change the frequency of the laser light for the chirping, while VCSELs (vertical-cavity surface-emitting lasers) are a type of inexpensive integrable semiconductor lasers with low power consumption.



Top 10 emerging technologies for 2014

Top 10 Emerging Technologies for 2014



Technology has become perhaps the greatest agent of change in the modern world. While never without risk, positive technological breakthroughs promise innovative solutions to the most pressing global challenges of our time, from resource scarcity to global environmental change. However, a lack of appropriate investment, outdated regulatory frameworks and gaps in public understanding prevent many promising technologies from achieving their potential.
The World Economic Forum’s Global Agenda Council on Emerging Technologies identifies recent key trends in technological change in its annual list of Top 10 Emerging Technologies. By highlighting the most important technological breakthroughs, the Council aims to raise awareness of their potential and contribute to closing gaps in investment, regulation and public understanding. For 2014, the Council identified ten new technologies that could reshape our society in the future.
The 2014 list is:

Body-adapted Wearable Electronics

Jogger runs around Chestnut Hill Reservoir in BostonFrom Google Glass to the Fitbit wristband, wearable technology has generated significant attention over the past year, with most existing devices helping people to better understand their personal health and fitness by monitoring exercise, heart rate, sleep patterns, and so on. The sector is shifting beyond external wearables like wristbands or clip-on devices to “body-adapted” electronics that further push the ever-shifting boundary between humans and technology.
The new generation of wearables is designed to adapt to the human body’s shape at the place of deployment. These wearables are typically tiny, packed with a wide range of sensors and a feedback system, and camouflaged to make their use less intrusive and more socially acceptable. These virtually invisible devices include earbuds that monitor heart rate, sensors worn under clothes to track posture, a temporary tattoo that tracks health vitals and haptic shoe soles that communicate GPS directions through vibration alerts felt by the feet. The applications are many and varied: haptic shoes are currently proposed for helping blind people navigate, while Google Glass has already been worn by oncologists to assist in surgery via medical records and other visual information accessed by voice commands.
Technology analysts consider that success factors for wearable products include device size, non-invasiveness, and the ability to measure multiple parameters and provide real-time feedback that improves user behaviour. However, increased uptake also depends on social acceptability as regards privacy. For example, concerns have been raised about wearable devices that use cameras for facial recognition and memory assistance. Assuming these challenges can be managed, analysts project hundreds of millions of devices in use by 2016.

Nanostructured Carbon Composites

A car drives into a heavily secured downtown the first day of the G20 Summit in PittsburghEmissions from the world’s rapidly-growing fleet of vehicles are an environmental concern, and raising the operating efficiency of transport is a promising way to reduce its overall impact. New techniques to nanostructure carbon fibres for novel composites are showing the potential in vehicle manufacture to reduce the weight of cars by 10% or more. Lighter cars need less fuel to operate, increasing the efficiency of moving people and goods and reducing greenhouse gas emissions.
However, efficiency is only one concern – another of equal importance is improving passenger safety. To increase the strength and toughness of new composites, the interface between carbon fibres and the surrounding polymer matrix is engineered at the nanoscale to improve anchoring – using carbon nanotubes, for example. In the event of an accident, these surfaces are designed to absorb impact without tearing, distributing the force and protecting passengers inside the vehicle.
A third challenge, which may now be closer to a solution, is that of recycling carbon fibre composites – something which has held back the widespread deployment of the technology. New techniques involve engineering cleavable “release points” into the material at the interface between the polymer and the fibre so that the bonds can be broken in a controlled fashion and the components that make up the composite can be recovered separately and reused. Taken together, these three elements could have a major impact by bringing forward the potential for manufacturing lightweight, super-safe and recyclable composite vehicles to a mass scale.

Mining Metals from Desalination Brine

Waves crash against a lighthouse during storms that battered Britain and where a 14-year-old boy was swept away to sea, at Newhaven in South East EnglandAs the global population continues to grow and developing countries emerge from poverty, freshwater is at risk of becoming one of the Earth’s most limited natural resources. In addition to water for drinking, sanitation and industry in human settlements, a significant proportion of the world’s agricultural production comes from irrigated crops grown in arid areas. With rivers like the Colorado, the Murray-Darling and the Yellow River no longer reaching the sea for long periods of time, the attraction of desalinating seawater as a new source of freshwater can only increase.
Desalination has serious drawbacks, however. In addition to high energy use (a topic covered in last year’s Top 10 Emerging Technologies), the process produces a reject-concentrated brine, which can have a serious impact on marine life when returned to the sea. Perhaps the most promising approach to solving this problem is to see the brine from desalination not as waste, but as a resource to be harvested for valuable materials. These include lithium, magnesium and uranium, as well as the more common sodium, calcium and potassium elements. Lithium and magnesium are valuable for use in high-performance batteries and lightweight alloys, for example, while rare earth elements used in electric motors and wind turbines – where potential shortages are already a strategic concern – may also be recovered.
New processes using catalyst-assisted chemistry raise the possibility of extracting these metals from reject desalination brine at a cost that may eventually become competitive with land-based mining of ores or lake deposits. This economic benefit may offset the overall cost of desalination, making it more viable on a large scale, in turn reducing the human pressures on freshwater ecosystems.

Grid-scale Electricity Storage

A tree stands near fog over the central Bosnian town of Vitez on the Lisac mountain range during sunsetElectricity cannot be directly stored, so electrical grid managers must constantly ensure that overall demand from consumers is exactly matched by an equal amount of power fed into the grid by generating stations. Because the chemical energy in coal and gas can be stored in relatively large quantities, conventional fossil-fuelled power stations offer dispatchable energy available on demand, making grid management a relatively simple task. However, fossil fuels also release greenhouse gases, causing climate change – and many countries now aim to replace carbon-based generators with a clean energy mix of renewable, nuclear or other non-fossil sources.
Clean energy sources, in particular wind and solar, can be highly intermittent; instead of producing electricity when consumers and grid managers want it, they generate uncontrollable quantities only when favourable weather conditions allow. A scaled-up nuclear sector might also present challenges due to its preferred operation as always-on baseload. Hence, the development of grid-scale electricity storage options has long been a “holy grail” for clean energy systems. To date, only pumped storage hydropower can claim a significant role, but it is expensive, environmentally challenging and totally dependent on favourable geography.
There are signs that a range of new technologies is getting closer to cracking this challenge. Some, such as flow batteries may, in the future, be able to store liquid chemical energy in large quantities analogous to the storage of coal and gas. Various solid battery options are also competing to store electricity in sufficiently energy-dense and cheaply available materials. Newly invented graphene supercapacitors offer the possibility of extremely rapid charging and discharging over many tens of thousands of cycles. Other options use kinetic potential energy such as large flywheels or the underground storage of compressed air.
A more novel option being explored at medium scale in Germany is CO2 methanation via hydrogen electrolysis, where surplus electricity is used to split water into hydrogen and oxygen, with the hydrogen later being reacted with waste carbon dioxide to form methane for later combustion – if necessary, to generate electricity. While the round-trip efficiency of this and other options may be relatively low, clearly storage potential will have high economic value in the future. It is too early to pick a winner, but it appears that the pace of technological development in this field is moving more rapidly than ever, in our assessment, bringing a fundamental breakthrough more likely in the near term.

Nanowire Lithium-ion Batteries

A vehicle trapped overnight by an ice storm sits abandoned on the Glenshane Pass in Northern IrelandAs stores of electrical charge, batteries are critically important in many aspects of modern life. Lithium-ion batteries, which offer good energy density (energy per weight or volume) are routinely packed into mobile phones, laptops and electric cars, to name just a few common uses. However, to increase the range of electric cars to match that of petrol-powered competitors – not to mention the battery lifetime between charges of mobile phones and laptops – battery energy density needs to be improved dramatically.
Batteries are typically composed of two electrodes, a positive terminal known as a cathode, and a negative terminal known as an anode, with an electrolyte in between. This electrolyte allows ions to move between the electrodes to produce current. In lithium-ion batteries, the anode is composed of graphite, which is relatively cheap and durable. However, researchers have begun to experiment with silicon anodes, which would offer much greater power capacity.
One engineering challenge is that silicon anodes tend to suffer structural failure from swelling and shrinking during charge-discharge cycle. Over the last year, researchers have developed possible solutions that involve the creation of silicon nanowires or nanoparticles, which seem to solve the problems associated with silicon’s volume expansion when it reacts with lithium. The larger surface area associated with nanoparticles and nanowires further increases the battery’s power density, allowing for fast charging and current delivery.
Able to fully charge more quickly, and produce 30%-40% more electricity than today’s lithium-ion batteries, this next generation of batteries could help transform the electric car market and allow the storage of solar electricity at the household scale. Initially, silicon-anode batteries are expected to begin to ship in smartphones within the next two years.

Screenless Display

An illustration picture shows a woman looking at the Facebook website on a computer in MunichOne of the more frustrating aspects of modern communications technology is that, as devices have miniaturized, they have become more difficult to interact with – no one would type out a novel on a smartphone, for example. The lack of space on screen-based displays provides a clear opportunity for screenless displays to fill the gap. Full-sized keyboards can already be projected onto a surface for users to interact with, without concern over whether it will fit into their pocket. Perhaps evoking memories of the early Star Wars films, holographic images can now be generated in three dimensions; in 2013, MIT’s Media Lab reported a prototype inexpensive holographic colour video display with the resolution of a standard TV.
Screenless display may also be achieved by projecting images directly onto a person’s retina, not only avoiding the need for weighty hardware, but also promising to safeguard privacy by allowing people to interact with computers without others sharing the same view. By January 2014, one start-up company had already raised a substantial sum via Kickstarter with the aim of commercializing a personal gaming and cinema device using retinal display. In the longer term, technology may allow synaptic interfaces that bypass the eye altogether, transmitting “visual” information directly to the brain.
This field saw rapid progress in 2013 and appears set for imminent breakthroughs of scalable deployment of screenless display. Various companies have made significant breakthroughs in the field, including virtual reality headsets, bionic contact lenses, the development of mobile phones for the elderly and partially blind people, and hologram-like videos without the need for moving parts or glasses.

Human Microbiome Therapeutics

MRSA bacteria strain is seen in a petri dish in a microbiological laboratory in BerlinThe human body is perhaps more properly described as an ecosystem than as a single organism: microbial cells typically outnumber human cells by 10 to one. This human microbiome has been the subject of intensifying research in the past few years, with the Human Microbiome Project in 2012 reporting results generated from 80 collaborating scientific institutions. They found that more than 10,000 microbial species occupy the human ecosystem, comprising trillions of cells and making up 1%-3% of the body’s mass.
Through advanced DNA sequencing, bioinformatics and culturing technologies, the diverse microbe species that cohabitate with the human body are being identified and characterized, with differences in their abundance correlated with disease and health.
It is increasingly understood that this plethora of microbes plays an important role in our survival: bacteria in the gut, for example, allow humans to digest foods and absorb important nutrients that their bodies would otherwise not be able to access. On the other hand, pathogens that are ubiquitous in humans can sometimes turn virulent and cause sickness or even death.
Attention is being focused on the gut microbiome and its role in diseases ranging from infections to obesity, diabetes and inflammatory bowel disease. It is increasingly understood that antibiotic treatments that destroy gut flora can result in complications such as Clostridium difficile infections, which can in rare cases lead to life-threatening complications. On the other hand, a new generation of therapeutics comprising a subset of microbes found in healthy gut are under clinical development with a view to improving medical treatments. Advances in human microbiome technologies clearly represent an unprecedented way to develop new treatments for serious diseases and to improve general healthcare outcomes in our species.

RNA-based Therapeutics

Handout image of structures found in the HIV RNA genome as identified by UNC researchersRNA is an essential molecule in cellular biology, translating genetic instructions encoded in DNA into the production of the proteins that enable cells to function. However, as protein production is also a central factor in most human diseases and disorders, RNA-based therapeutics have long been thought to hold the potential to treat a range of problems where conventional drug-based treatments cannot offer much help. The field has been slow to develop, however, with initial high hopes being dented by the sheer complexity of the effort and the need to better understand the variability of gene expression in cells.
Over the past year, there has been a resurgence of interest in this new field of biotech healthcare, with two RNA-based treatments approved as human therapeutics as of 2014. RNA-based drugs for a range of conditions including genetic disorders, cancer and infectious disease are being developed based on the mechanism of RNA interference, which is used to silence the expression of defective or overexpressed genes.
Extending the repertoire of RNA-based therapeutics, an even newer platform based on messenger RNA (mRNA) molecules is now emerging. Specific mRNA sequences injected intramuscularly or intravenously can act as therapeutic agents through the patient’s own cells, translating them into the corresponding proteins that deliver the therapeutic effect. Unlike treatments aimed at changing DNA directly, RNA-based therapeutics do not cause permanent changes to the cell’s genome and so can be increased or discontinued as necessary.
Advances in basic RNA science, synthesis technology and in vivo delivery are combining to enable a new generation of RNA-based drugs that can attenuate the abundance of natural proteins, or allow for the in vivo production of optimized, therapeutic proteins. Working in collaboration with large pharmaceutical companies and academia, several private companies that aim to offer RNA-based treatments have been launched. We expect this field of healthcare to increasingly challenge conventional pharmaceuticals in forging new treatments for difficult diseases in the next few years.

Quantified Self (Predictive Analytics)

A woman speaks on her iPhone as she walks on a busy street in downtown ShanghaiThe quantified-self movement has existed for many years as a collaboration of people collecting continual data on their everyday activities in order to make better choices about their health and behaviour. But, with today’s Internet of Things, the movement has begun to come into its own and have a wider impact.
Smartphones contain a rich record of people’s activities, including who they know (contact lists, social networking apps), who they talk to (call logs, text logs, e-mails), where they go (GPS, Wi-Fi, and geotagged photos) and what they do (apps we use, accelerometer data). Using this data, and specialized machine-learning algorithms, detailed and predictive models about people and their behaviours can be built to help with urban planning, personalized medicine, sustainability and medical diagnosis.
For example, a team at Carnegie Mellon University has been looking at how to use smartphone data to predict the onset of depression by modelling changes in sleep behaviours and social relationships over time. In another example, the Livehoods project, large quantities of geotagged data created by people’s smartphones (using software such as Instagram and Foursquare) and crawled from the Web have allowed researchers to understand the patterns of movement through urban spaces.
In recent years, sensors have become cheap and increasingly ubiquitous as more manufacturers include them in their products to understand consumer behaviour and avoid the need for expensive market research. For example, cars can record every aspect of a person’s driving habits, and this information can be shown in smartphone apps or used as big data in urban planning or traffic management. As the trend continues towards extensive data gathering to track every aspect of people’s lives, the challenge becomes how to use this information optimally, and how to reconcile it with privacy and other social concerns.

Brain-computer Interfaces

Chilean software engineer Jorge Alviarez, places head sensors on Jenifer Astorga, who suffers from quadriplegia, during a training session for her in Valparaiso city.The ability to control a computer using only the power of the mind is closer than one might think. Brain-computer interfaces, where computers can read and interpret signals directly from the brain, have already achieved clinical success in allowing quadriplegics, those suffering “locked-in syndrome” or people who have had a stroke to move their own wheelchairs or even drink coffee from a cup by controlling the action of a robotic arm with their brain waves. In addition, direct brain implants have helped restore partial vision to people who have lost their sight.
Recent research has focused on the possibility of using brain-computer interfaces to connect different brains together directly. Researchers at Duke University last year reported successfully connecting the brains of two mice over the Internet (into what was termed a “brain net”) where mice in different countries were able to cooperate to perform simple tasks to generate a reward. Also in 2013, scientists at Harvard University reported that they were able to establish a functional link between the brains of a rat and a human with a non-invasive, computer-to-brain interface.
Other research projects have focused on manipulating or directly implanting memories from a computer into the brain. In mid-2013, MIT researchers reported having successfully implanted a false memory into the brain of a mouse. In humans, the ability to directly manipulate memories might have an application in the treatment of post-traumatic stress disorder, while in the longer term, information may be uploaded into human brains in the manner of a computer file. Of course, numerous ethical issues are also clearly raised by this rapidly advancing field.

Excel Formula's (Regular & Job-Oriented)

 Excel Formula's  1) SUM Task: Sum of numbers Formula: =SUM(A1:A10) Example: Sum of all numbers in A1–A10 2) AVERAGE Task: Average Formu...